Bioprospective screening and characterization of isolates from Pterocarpus osun leaf and stem bark extracts

Antimicrobial resistance (AMR) ranks among the top 10 world health challenges of 21st century, predicted that it will cause approximately million deaths in 2050. Therefore, more investigation into identifying new antibiotics from natural sources is inevitable. Compounds leaf and stem bark Pterocarpus osun were isolated using column chromatography, screened for their bioactivities, characterized FTIR spectroscopy method ongoing search novel antimicrobial therapies. The isolates tested antibacterial antifungal activities against eleven pathogenic organisms. zones inhibition ranged diameter 22 to 30 mm. minimum inhibitory concentrations determined. Thin-layer chromatography was used determine purity compounds, retention factor calculated. This between 0.2424 0.8151. melting points compounds also recorded, as are spectra ranging 4000 400 cm-1. Some peaks recorded typical single bond (4000-25000 cm-1), double (2000-1500 cm-1) with confirmation fingerprint (1500-400 region but none triple (2500-2000 spectra. screening results show identified can potentially lead discovery antibiotic medications.